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Ospreys Cup Under 16 2013 - 2014
Brad Barritt, Tom Wood, Geoff Parling and Kyle Eastmond are ruled out of England's Six Nations opener against Wales on 6 February.
Sale's Mark Cueto - who came within inches of scoring for England in the 2007 World Cup final - will retire at the end of the season.
Wales captain Sam Warburton is relishing "being thrown straight into the deep end" as his team open the Six Nations against England.
Ex-England prop Paul Doran Jones will rejoin Gloucester, while fellow props Paddy McAllister and Nicky Thomas also sign.
Former Wales wing Shane Williams urges Warren Gatland to pick Liam Williams for their Six Nations opener against England.